| abstract |
The invention discloses pyridopyrimidine compounds with a general formula (I), wherein Ar is aryl or heteroaryl; R1 is hydrogen, halogen, amino, heterocyclic group, alkyl, aminoalkyl, heterocyclic alkyl, aryl, heteroaryl, cyano, alkenyl or alkynyl; R2 is C1-C6 alkyl; n is an integer from 0 to 4; and when n is greater than or equal to 2, two R1 can be combined with a morpholine ring into a fused ring, bridge ring or spiro-ring. The invention also discloses a preparation method of the compounds with a general formula (I) as well as a pharmaceutical composition thereof and an application thereof as a PI3K/mTOR inhibitor. |