http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104557737-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-74 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-74 |
| filingDate | 2015-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104557737-B |
| titleOfInvention | A kind of synthetic method of 2-aryl substituted quinazoline pharmaceutical intermediate |
| abstract | The invention provides a kind of synthetic method of 2-aryl substituted quinazoline compound shown in a kind of formula (III), The method comprises: in an organic solvent, in the presence of a catalyst, an organic ligand, a base and an auxiliary agent, the compound of the formula (I) and the formula (II) seals the reaction at 90-110° C. in an inert protective atmosphere 5-8 Hours, natural cooling after completion of the reaction, vacuum concentration, column chromatography purification, and obtain the compound of the formula (III), Wherein, R 1 and R 2 are each independently selected from H, halogen, C 1 ‑C 6 alkyl, C 1 ‑C 6 alkoxy, nitro or amino; the method is selected through the selection of suitable catalysts, bases and auxiliary agents , and achieved a high yield of 2-aryl substituted quinazoline pharmaceutical intermediates, the reaction temperature is low, the reaction time is short, has significant industrial advantages, can fully meet the needs of the field of drug synthesis, and has industrialization potential. |
| priorityDate | 2015-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 13.