http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104557582-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d40285e27f4ed83b8728b0d477404958 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-28 |
| filingDate | 2015-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f50be6563a2d9f9539128a76f6800d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_343cf4e3bc238670fe6f2ace79fc6048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_215e3ccd15a31ce8b547a10b5937e15e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01494df390579776390a9edf690ac971 |
| publicationDate | 2015-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104557582-A |
| titleOfInvention | A kind of preparation method of saxagliptin intermediate |
| abstract | The present invention provides a kind of preparation method of saxagliptin intermediate shown in formula (V): (1) under solvent-free condition, formula (I), formula (II), TMSCN in the presence of catalyst A, in 0～ React at 70°C for 1-8 hours, quench the reaction after the end of the reaction, separate and purify the reaction mixture to obtain formula (III); (2) add formula (III) and acid into water, heat and reflux at 50-120°C for 3-10 hours Hydrolysis reaction, adjust pH=4～5 with alkali solution after reaction finishes, reactant solution is separated and purified to obtain formula (IV); (3) formula (IV) is dissolved in organic solvent, adds catalyst B, feeds hydrogen, at 20 Stir under normal pressure at ~60°C for 4 to 12 hours. After the reaction, the reaction solution is separated and purified to obtain the saxagliptin intermediate shown in formula (V); the method of the present invention has the advantages of mild reaction conditions, simple and convenient operation, and high atom utilization , environmental friendliness, low production cost and other advantages; |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106674031-A |
| priorityDate | 2015-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.