| abstract |
The invention discloses a kind of application of quinolinones compound as hCBS enzyme inhibitors, and in particular to application of 7 amino of compound, 2 hydroxyl, 5 imino group, 6,7 dihydroquinoline, 8 (5H) ketone as hCBS enzyme inhibitors.The micromolecular compound is 5,7 diamino quinolinones compounds, to the IC of in vitro hCBS enzymatic reactions 50 For 4 μM, research H can be used as 2 Instrument medicine and exploitation treatment circulation shock, apoplexy, Down's syndrome and tumour of S signal paths etc. and H 2 The lead compound of the drug for the disease that S-phase is closed. |