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publicationDate 2015-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-104531798-A
titleOfInvention Method for improving output of tetraene macrolide antibiotics
abstract The invention discloses a method for improving output of tetraene macrolide antibiotics and belongs to the technical field of microorganisms. According to the method, 100mu g/mL paromomycin is added in a solid medium which is used for culturing Streptomyces diastatochromogenes D to obtain a Streptomyces diastatochromogenes mutant strain which has relatively good resistance to the paromomycin; the capacity of synthesizing the tetraene macrolide antibiotics of the mutant strain is stronger than that of the Streptomyces diastatochromogenes D.
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