http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104530198-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-16 |
| filingDate | 2014-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104530198-B |
| titleOfInvention | A kind of method that fragment condensation prepares desmopressin acetate |
| abstract | The invention discloses a kind of method that fragment condensation prepares desmopressin acetate, solid phase prepares the first peptide fragment sequences resin of full guard, and oxidation forms disulfide bond in solid phase, is then cleaved the first peptide fragment sequences of the full guard of cyclisation from resin；First peptide fragment sequences of the full guard being cyclized in liquid phase and H Gly NH 2 It is condensed to yield full guard minirin；Then slough Side chain protective group and obtain the thick peptide of minirin, purifying turns salt and obtains desmopressin acetate；Wherein, the first described peptide fragment sequences are the 1st~8 amino acids of desmopressin acetate.The method that the present invention is combined using solid liquid phase prepares desmopressin acetate, improves yield and purity, due to causing cost to reduce using 2 chlorine trityl chloride resins and solid phase cyclization, beneficial to large-scale production. |
| priorityDate | 2014-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 111.