http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104530002-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-454 |
| filingDate | 2015-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104530002-B |
| titleOfInvention | Bilastine compound and preparation method thereof |
| abstract | The invention belongs to pharmaceutical technology field, and in particular to a kind of bilastine compound, and the compound preparation method, bilastine compound stability provided by the present invention is good, even if moisture absorption weightening is also not substantially under high humidity conditions, relevant material does not increase；Bilastine solubility compared with other crystalline state is high, high specific surface area.Its preparation method is to be initiation material to methyl benzyl carbinol; sulphonic acid ester is obtained in the sulfonylation that hydroxyl is carried out through sulfonic acid chloride; it is condensed with the piperidylbenzimidazol of 1 ethoxyethyl group 2 again; in benzyl position bromination; through grignard reaction after benzyl position introduces carboxyl by converting carboxylate groups into ester; di-methylation is carried out in benzyl position with iodomethane again, be finally hydrolyzed prepared bilastine.The route totally seven step synthetic reaction, there is that synthesis step is few, reaction condition is gentle, and raw material is easy to get, course of reaction simple, high income, cost is relatively low, be easy to industrialization, the advantage that three-waste pollution is few. |
| priorityDate | 2015-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 87.