abstract |
The present invention relates to a class of 7-amide-brefeldin A derivatives with anti-tumor activity and their preparation and application. The new compounds provided by the present invention are effective against liver cancer, lung cancer, breast cancer, kidney cancer, colon cancer and prostate cancer It has high curative effect, and the effective inhibition rate is as high as 80% in vitro; the method for obtaining the 7-NH 2 -brefeldin A and 7-amide-brefeldin A derivatives of the present invention is simple and easy to operate. |