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filingDate 2014-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2018-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2018-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-104529889-B
titleOfInvention A kind of dehydration C- alkylations of heterocyclic methyl compound
abstract The invention discloses a kind of dehydration C alkylations of heterocyclic methyl compound, dehydration C alkylated reactions synthesizing alkylated heterocyclic compound is carried out in the presence of without catalyst using alcohol as alkylating reagent, with heterocyclic methyl compound, and alcohol directly can carry out dehydration C alkylated reactions in the presence of air and alkali with heterocyclic methyl compound to methyl position, reaction temperature is 100~180 DEG C, reaction time is 6~60 hours, the solvent of reaction is organic solvent, and by-product is water.This method is alkylating reagent using alcohols that is cheap and easy to get, deriving from a wealth of sources, stablize low toxicity, does not use catalyst, in the presence of air and alkali, the heterocyclic compound directly synthesizing alkylated through being dehydrated C alkylated reactions.Requirement to reaction condition is relatively low, has the wider scope of application, should also have certain research and prospects for commercial application.
priorityDate 2014-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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