http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104529864-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_72ccbbb85ff81e71cd965f1b761c095f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-12 |
| filingDate | 2014-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a371ae9e590056d5075304edb5476e44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b537b531195b0b8c0d25bcd70eecf5b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_132def5bdd505d9363476b127e9fbbef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79e41870df1ab3fbc0342e4c113433df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5052fa3dffd010cfcf5dae3c5e6c1fd5 |
| publicationDate | 2015-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104529864-A |
| titleOfInvention | A kind of preparation method of bazedoxifene acetate crystal form A |
| abstract | The invention belongs to the technical field of chemical pharmacy, and relates to a preparation method of bazedoxifene acetate crystal form A. The preparation method of bazedoxifene acid according to the present invention comprises the following steps: step 1, under the condition of using palladium carbon as a catalyst, dissolving hexamethyleneimine benzyloxyindole and ammonium formate in benign organic Reaction in a solvent; step 2, filter out palladium carbon after the reaction is complete, add acetic acid and a poor organic solvent after the filtrate is cooled, stir, crystallize, then filter and dry to obtain the crude product of crystal form A; step 3, in the presence of an inert gas protection , dissolve the crude crystal form A in a benign organic solvent, and heat to dissolve; Step 4, hot filter the solution, add a poor organic solvent dropwise to the filtrate after cooling, and crystallize; Step 5, after the crystallization is completed, filter the solution, and dry the solid to obtain Bazedoxifene acetate crystal form A. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106748959-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111004165-A |
| priorityDate | 2014-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.