http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104529813-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-24 |
| filingDate | 2014-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104529813-B |
| titleOfInvention | A kind of 2-acetyl group-2-goes the preparation method of amide groups tetracycline |
| abstract | The present invention relates to a kind of 2 acetyl group 2 and go the preparation method of amide groups tetracycline; the method be with by the carbamide double salt mother solution in quadracycline production process after concentrating under reduced pressure; inject in high performance liquid chromatograph, collect 2 acetyl group 2 and go amide groups tetracycline；Go amide groups tetracycline pH to be adjusted to neutrality 2 acetyl group 2 separated, be gradually added into sodium chloride, make acetonitrile and water stratification; 2 acetyl group 2 go amide groups tetracycline to be extracted in acetonitrile layer, divide and take acetonitrile layer, then add appropriate acetonitrile toward water layer; shaking; stand, divide and take acetonitrile layer, merge twice acetonitrile; put in freezer compartment of refrigerator and stand overnight; filter immediately after taking-up, take filtrate reduced in volume and be dried, obtain 2 acetyl group 2 and go amide groups tetracycline sterling.Present invention process is easy, has efficient, quick, response rate high. |
| priorityDate | 2014-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.