http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104529798-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C223-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C221-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-61 |
| filingDate | 2014-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104529798-B |
| titleOfInvention | A kind of preparation method of Etoricoxib intermediate 3-amino-2-chloroacrolein |
| abstract | The invention discloses a kind of preparation method of Etoricoxib intermediate 3-amino-2-chloroacrolein.The method take mucochloric acid as starting raw material, and mucochloric acid first reacts with open-chain crown ether, obtains intermediate 7; Intermediate 7 is hydrolyzed and obtains intermediate 8 in organic acid, and intermediate 8 is obtained by reacting 3-amino-2-chloroacrolein in ammoniacal liquor.The open-chain crown ether that the present invention adopts is solid, and toxicity is little, and nucleophilicity is stronger than aniline, and yield is high; This invention simplifies operation steps, reduce production cost, be more conducive to the carrying out of industrialization reaction; Last handling process of the present invention is more simple, on the basis of improving dust removal rate, reduce further the complicacy of technological operation. |
| priorityDate | 2014-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.