http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104497009-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 2014-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104497009-B |
| titleOfInvention | A kind of simple and convenient process for preparing of Bio |
| abstract | The present invention relates to the simple and convenient process for preparing of a kind of Bio.The method includes: Cys ester hydrochloride and 6-halo alkyl caproate (II) are substituted reaction under acid binding agent effect and prepare (S)-2-amino-4-sulfur for dibutoxyethyl sebacate, then N-is Benzylation, sulfide oxidation becomes sulfone, intramolecular cyclization prepares (S)-2-ester group normal-butyl-4-benzylamino tetrahydro thiophene-3-ketone oxysulfide (V), carry out amidatioon cyclization again, deoxidation and reduction prepares 5-(6aR1-benzyl-2-oxo-5, 6-dihydro-thiophene also [3, 4-d] imidazol-4 yl) valerate (VII), through catalytic hydrogenation, Bio is prepared in hydrolysis.Raw material of the present invention is cheap and easy to get, and reaction condition is easily operated, and operating process is short, safety and environmental protection, and product cost is low, is suitable to industrialized production. |
| priorityDate | 2014-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 127.