http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104496899-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 |
| filingDate | 2015-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104496899-B |
| titleOfInvention | The synthetic method of the intermediate of Menglusitena |
| abstract | The invention provides a kind of synthetic method of the intermediate of Menglusitena, comprise the following steps：（a）Make formula（ ）Compound and formula（ ）Compound in organic solvent, reacted at 50 ~ 140 DEG C, production（ ）Compound；（b）Make formula（ ）Compound and formula（ ）Compound in organic solvent, in the presence of palladium catalyst at a temperature of 50 ~ 140 DEG C occur Heck reaction, production（ ）Compound；（c）Make formula（ ）Compound and step（a）The formula of middle gained（ ）Compound in organic solvent, in the presence of palladium catalyst at a temperature of 50 ~ 140 DEG C occur Heck reaction, production（ ）Compound；The method of the present invention shortens reactions steps, improves total recovery, and rear two step can be carried out using one kettle way, reduce the consumption of expensive catalyst, reduce cost, it is adaptable to industrialized production；The reaction scheme of the method is as follows： Wherein, X is Br or I, R are alkyl or benzyl. |
| priorityDate | 2015-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 108.