http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104478997-B
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P39-06 |
filingDate | 2014-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2018-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2018-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-104478997-B |
titleOfInvention | A kind of synthetic method of fullerene cyclic peptide |
abstract | The invention discloses a kind of fullerene cyclic peptide and its synthetic methods, and the cyclic peptide with protecting group is dissolved in DMF, when adding in succinic anhydride and small N methylmorphine woodss normal-temperature reaction 0.2 ~ 5, are then extracted;The product being obtained by extraction is dissolved in fullerene list addition pyrrolidines in DCM and DMF mixed liquors, when then addition DCC, HOBT and DMAP normal-temperature reaction 20 ~ 100 is small, carries out column chromatography;The product that column chromatography obtains is dissolved in TFA/DCM mixed liquors, when normal-temperature reaction 1 ~ 6 is small, then adds in ice ether, 4 DEG C overnight, and yellowish color substance is precipitated, and target product is obtained after dry.The fullerene cyclic peptide that the present invention obtains can promote the stability of polypeptide in vivo, and with good active anticancer;Cyclic peptide has stronger acceptor binding force and receptor-specific than corresponding linear peptides, has the efficient targeting to cancer cell and the efficient characteristic for removing free radical, is good antioxidant. |
priorityDate | 2014-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.