http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104478973-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-08 |
| filingDate | 2014-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104478973-B |
| titleOfInvention | It is a kind of to recrystallize the method for reducing spiramvcin impurity |
| abstract | A kind of to recrystallize the method for reducing the mould impurity of spiral, step is：(1) it is potassium dihydrogen phosphate is soluble in water, it is then 2~3 with careless acid for adjusting pH value；(2) by the mixed solution obtained by solid-state spiramvcin input step (1), keeping temperature is 25~40 DEG C of stirring and dissolvings；(3) it is 12~15% sodium hydroxide solutions to mass concentration is added in step (2) gained spiramvcin solution, heat up 60~90min, and then keeping temperature is stirred crystallization at 50~65 DEG C；(4) wet-milling is centrifugally separating to obtain, wet-milling repeat step (1), (2), (3) operate, wet-milling drying is obtained again can obtain low impurity spiramvcin.This method is the dosage by changing potassium dihydrogen phosphate and oxalic acid, during spiramvcin finished product is then re-dissolved into potassium dihydrogen phosphate and oxalic acid solution, is recrystallized, and the relevant material in spiramvcin is further removed, and then improve product quality. |
| priorityDate | 2014-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.