| abstract |
It is the hydrogen on the hydroxyl of hyaluronic acid or its salt by group the invention discloses a kind of high molecular weight hydroxyalkylation hyaluronic acid or its saltnn Compound is formed by after substitution, wherein R2 is the branched of hydrogen atom or carbon atom number 1 ~ 10 or the alkyl of straight-chain. The invention also discloses preparation methods and application. Preparation process of the present invention is simple, mild condition, the product that available molecular weight is high, degree of substitution is low, the hydroxyalkylation product antihyaluronidase enzymolysis property is prominent, has excellent lubricity, viscoelasticity and biocompatibility, has good application in terms for the treatment of Osteoarthritis, scapulohumeral periarthritis. |