http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104447868-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C57-15 |
| filingDate | 2014-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104447868-B |
| titleOfInvention | A kind of preparation method of tenofovir disoproxil fumarate |
| abstract | A preparation method for tenofovir disoproxil fumarate, belongs to tenofovir disoproxil fumarate synthesis technical field. Comprise the following steps: prepare tenofovir two pyrrole furan esters, prepare tenofovir disoproxil fumarate crude product, refine tenofovir disoproxil fumarate. Wherein refining tenofovir disoproxil fumarate step adopts 65% ethanolic solution as tenofovir disoproxil fumarate recrystallization solvent, places 3 ~ 6 hours natural crystallization in 5 ~ 10 degrees Celsius of environment of low temperature. Preparation method of the present invention has overcome organic residue and the too high problem of side reaction thing in tenofovir disoproxil fumarate preparation process, total recovery can reach more than 40%, and in end product, tenofovir disoproxil fumarate content is high, recrystallization process is easy and simple to handle, cost is low, without poisonous and harmful side reaction and product. |
| priorityDate | 2014-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.