http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104447793-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf8e375c4478d202973b3ad87d3f48ef |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-46 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-04 |
| filingDate | 2014-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0250dbe57d75468cbe96ac2ebe87109 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25865e8bc41b0b8e5056643a2cb8c707 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e55ceb24f4f33b775dba3a8037dfa3cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64e8c40cbd47d66ad76c97de51bc34ba |
| publicationDate | 2015-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104447793-A |
| titleOfInvention | Improved process for cephalosporin intermediate penicillin sulfoxide |
| abstract | The invention discloses an improved process for cephalosporin intermediate penicillin sulfoxide. The improved process comprises the following steps: with penicillin G sylvite as a raw material, oxidizing with 8.5% peracetic acid, wherein the molar ratio of the penicillin G sylvite to the peracetic acid is (1.0-1.5) to 1; adding sulfuric acid of which the concentration is 3M to adjust pH to be 1-2 after reaction is ended; acidifying and crystallizing to obtain penicillin sulfoxide with crystal water; dissolving a product into butyl acetate, drying and dewatering in vacuum at 50 DEG C when the vacuum degree is 0.1MPa, so as to obtain white crystal penicillin sulfoxide; and dewatering the white penicillin sulfoxide, so as to obtain the penicillin sulfoxide. The improved process has the beneficial effects that with low-concentration peracetic acid as an oxidant, the reaction condition is mild; the oxidized penicillin sulfoxide contains two crystal water; through azeotropic reduced pressure removal of the butyl acetate and water, the overall production process is simple; the yield is high; and the prepared product is high in purity, and completely accords with the standard for cephalosporin medicine production. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111187282-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113214292-A |
| priorityDate | 2014-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.