| abstract |
The present invention relates to substituted pyrazole derivatives and stereoisomers, geometric isomers, tautomers, nitrogen oxides, solvates, hydrates, metabolites, esters, and the like for inhibiting overexpression of protein kinases. Pharmaceutically acceptable salts or its prodrugs, and pharmaceutical compositions containing these compounds as active ingredients, and the compounds and their pharmaceutical compositions are used to prepare drugs for preventing, treating, treating or alleviating abnormal cell growth diseases in patients Drug use. |