http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104447697-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2014-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104447697-B |
| titleOfInvention | A kind of preparation method of dabigatran etexilate intermediate |
| abstract | A kind of method that the invention discloses dabigatran etcxilate main intermediate, key step is as follows: 3 [4 methylamino 3 amino N (2 pyridine radicals) benzamido] ethyl acrylate and ethyl chloroacetate are joined mixed dissolution in reaction dissolvent by (1), is subsequently adding immobilized enzyme reaction；(2) remove immobilized enzyme after reaction terminates, obtain organic layer；(3) organic layer is boiled off reaction dissolvent, obtain grease and add acetic acid back flow reaction；(4) reaction boils off glacial acetic acid after terminating, and adds ethyl acetate and purified water, extraction, is evaporated by gained organic layer and i.e. obtains beta Alanine N [[1 methyl 1H benzimidazole 2 chloromethyl] 5 carbonyls] N 2 pyridine ethyl ester.The method of the invention is simple to operate, reaction condition is gentle, can be easily obtained high purity product, yield is higher, and enzyme can reuse, and has good industrial applications prospect. |
| priorityDate | 2014-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.