http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104447606-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-17 |
| filingDate | 2014-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104447606-B |
| titleOfInvention | A kind of synthetic method and application of 2-carbonyl-4-alkene-5-bromo-1,3-oxazine compound |
| abstract | The invention provides 2-carbonyl-4-alkene-5-bromo-1,3-oxazine compound and its synthesis method and application. The method comprises: reacting the compound shown in formula I with dibromodimethylhydantoin under the action of scandium trifluoromethanesulfonate/phosphorus oxygen ligand and sodium chloride to obtain 2-carbonyl group shown in formula II -4-alkene-5-bromo-1,3-oxazine compound. The present invention uses compounds shown in formula I of different structures and dibromodimethylhydantoin as raw materials, and under the action of scandium trifluoromethanesulfonate/phosphorus oxygen ligand and sodium chloride, effectively synthesizes 2 with optical activity. -Carbonyl-4-alkene-5-bromo-1,3-oxazine compound. This kind of compound can easily obtain various compounds containing 1,3-hydroxylamine structure by decarbonyl ring opening, and at the same time, an alkene and a bromine atom can be introduced in the reaction, and these functional groups can be further transformed to introduce other functional groups , has great application value. The method of the invention has the advantages of easy synthesis of raw materials, mild reaction conditions, simple and convenient operation, high regioselectivity, enantiomeric excess up to 99%, and yield up to 91%. |
| priorityDate | 2014-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 18.