| abstract |
The present invention relates to a surface-exposed protein (Protein E; pE), which is a virulence factor and can be detected in Haemophilus influenzae, which has the amino acid sequence shown in SEQ ID NO: 1; the present invention relates to the surface-exposed protein and a recombinant immunogenic protein based on the surface exposed protein (pE(A)) or a truncated variant thereof. The invention also describes nucleic acid sequences, vaccines, plasmids and phages, non-human hosts, recombinant nucleic acid sequences, fusion proteins and fusion products. The present invention also discusses methods of recombinantly producing the proteins or truncated fragments thereof. |