http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104419743-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate | 2013-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104419743-B |
| titleOfInvention | A kind of simulate in tumor hypoxia microenvironment cell ball invasion and attack and the method for drug evaluation |
| abstract | A kind of simulate in tumor hypoxia microenvironment cell ball invasion and attack and the method for drug evaluation, the cell ball of specific patternization arrangement is obtained first with the polydimethylsiloxane micro-hole chip that can be used for cell inoculation sedimentation glomeration, embedding through collagen extracellular matrix, it is achieved the patterned arrangement in cell ball three dimensional matrix is used for follow-up invasion and attack real-time monitored and related drugs evaluation study.Significantly, since achieve collagen stroma to the comprehensive parcel of cell ball and to cause a certain degree of anoxia, simulate real tumor hypoxia microenvironment.The method can simulate the behaviors such as solid tumor invasion and attack under anoxia matrix environment, the thinking carried out providing more clinical meaning for in-vivo tumour research that under this external model, tumor cell gene expression, signal path and drug evaluation etc. are investigated easy, truly without special hypoxia device. |
| priorityDate | 2013-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.