http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104418990-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N1-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F292-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F230-06 |
| filingDate | 2013-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104418990-B |
| titleOfInvention | Organic and inorganic hybrid microsphere particle, preparation and application thereof |
| abstract | The invention belongs to the technical fields of polymer materials and analysis, relates to a monodispersed organic and inorganic hybrid microsphere particle with core-shell structure and preparation and application thereof. Inorganic silica particles as the core are modified by a silanizing agent, and then 3-acetylaminophenylboronic acid and polyene cross-linking monomer coat on the click nuclear surface through a mercaptan-alkene click chemistry technology to form organic and inorganic hybrid nano / micron particles with core-shell structure, smooth surface and boric acid functional groups. According o the invention, introduction of the phenyl boronic acid functional group to the material surface by a mercaptan-alkene method not only overcomes the shortcomings of complex procedure and low reaction efficiency in a post modification method but also allows stable polymerization of APBA, increases surface bonding amount of boric acid and hydrophilic property of the material, and reduces the nonspecific adsorption of proteins. The microsphere particles of the invention can be used in separation or enrichment of glycoprotein with 1,2-cis diol structure, and has good practical value and application prospect in the field of proteomics. |
| priorityDate | 2013-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.