http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104402902-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-06 |
| filingDate | 2014-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104402902-B |
| titleOfInvention | Chirality 7-(the pyrazoles aldehyde contracting isoniazid hydrazone that piperazine replaces) fluoroquinolone carboxylic derivatives and its preparation method and application |
| abstract | The invention discloses a kind of chirality 7-(the pyrazoles aldehyde contracting isoniazid hydrazone that piperazine replaces) fluoroquinolone carboxylic derivatives and its preparation method and application, described chirality 7-(the pyrazoles aldehyde contracting isoniazid hydrazone that piperazine replaces) fluoroquinolone carboxylic derivatives is for having the compound of general structure (I), wherein, R 1 For H, methyl or ethyl; R 2 For H or methyl. Chirality 7-of the present invention (piperazine replace pyrazoles aldehyde contracting isoniazid hydrazone) fluoroquinolone carboxylic derivatives, is effectively combined into fluoquinolone, isoniazid, pyrazoles aldehyde hydrazone three the compound of a new construction; Reach active stack and cooperation; Realize the stack of three pharmacophores of isoniazid-pyrazoles hydrazone-fluoquinolone, increase treating tuberculosis activity, fluoquinolone and isoniazid are reduced to Normocellular toxic and side effect, also reduced the probability of branch tubercle bacillus to such medicine generation resistance, can be used as the antituberculotic for the treatment of tuberculosis active material exploitation brand new simultaneously. |
| priorityDate | 2014-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.