http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104402877-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-10 |
| filingDate | 2014-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104402877-B |
| titleOfInvention | Preparation method of atropine sulphate |
| abstract | The invention discloses a preparation method of atropine sulphate and solves the problem that an intermediate alpha-formoxyl phenylacetic acid tropeine is incompletely hydrolyzed in sulfuric acid and poor in hydrolysis effect in a single solvent, and an atropine crude product salt forming process is tedious in operation. The preparation method specifically comprises the following steps: I, adding potassium borohydride into a mixture containing alpha-formoxyl phenylacetic acid tropeine, alcohol and chloroform; II, adding an appropriate amount of water into the mixture and separating out an organic layer; III, distilling the organic layer to recover chloroform so as to obtain a faint yellow oily liquid; IV, adding acetone into the faint yellow oily liquid for freezing crystallization to obtain an atropine crude product; V, dropwise adding sulfuric acid into a solution containing the mixed solvent and the atropine crude product to adjust the pH of the solution to be greater than 4 but less than 7 at the temperature of 5 DEG C below zero to 10 DEG; VI, freezing the mixture overnight and crystallizing, filtering and drying to obtain atropine sulphate white crystals. The preparation method disclosed by the invention not only greatly improves the content and molar yield of the atropine sulphate crude product, but also lowers the cost to a great extent, and further has the characteristics of being simple and convenient to operate. |
| priorityDate | 2014-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.