http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104402831-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2014-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104402831-B |
| titleOfInvention | -5-cyanopyrimidine derivative containing uride construction unit and its production and use |
| abstract | The invention belongs to medicinal chemistry art, disclose a class and there is 5 cyanopyrimidine derivatives containing uride construction unit, its preparation method and the purposes in medicament research and development of anti-tumor activity.The present invention constructs pyrimidine parent nucleus with three component one kettle ways, use pharmaceutical chemistry principle of hybridization will have antineoplastic active fragment uride structure and be incorporated into parent nucleus, obtain the basic framework of this series compound, be prepared for a series of 5 cyanopyrimidine derivatives containing uride construction unit through the reaction such as chloro and amination again.The compounds of this invention formula is as shown in I. Anti tumor activity in vitro evaluation result proves, this compounds has significantly suppression and lethal effect to kinds of tumor cells EC 109, MCF 7, MGC 803, B16 F10, can be applied to prepare antitumor drug as the candidate of exploitation further or lead compound. |
| priorityDate | 2014-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.