| abstract |
The present invention is provided to treating the medicament of following disease：The disease relevant with the cholinergy of central nervous system (CNS) and/or peripheral nervous system (PNS) disease relevant with smooth muscle contraction, endocrine disorder, neurodegenerative disorders etc., described medicament comprises formula (I) compound：Wherein, A is CR 1E Or nitrogen-atoms, X Y Z is N CO NR 3A R 3B Deng R 1A To R 1E It is each independently hydrogen atom etc., R 2A To R 2D It is each independently hydrogen atom etc., R 3A And R 3B It is each independently the C being optionally substituted 3‑10 Cycloalkyl etc., and n is 1 or 2 or its pharmaceutically acceptable salt, and it goes out potent adjustment effect to the activities present of alpha 7 nicotinic acetylcholinergic receptor (α 7 nAChR). |