| abstract |
A kind of indane sulfonamide compounds of novelty, such as N-[(1S)-2,2,5, fluoro-2, the 3-dihydro-1H-indenes-1-bases of 7-tetra-] sulphonamide, N-[(1S)-2,2,4, fluoro-2, the 3-dihydro-1H-indenes-1-bases of 7-tetra-] sulphonamide and (+)-N-(2,2,4, fluoro-2, the 3-dihydro-1H-indenes-1-bases of 6,7-five) sulphonamide, or its pharmacy acceptable salt has the effect improving outbreak seriousness (scoring) in mouse kindling model, and therefore can expect as epilepsy therapy agent. |