| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4423185f79003e8f9b981e29323454a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-233
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 |
| filingDate |
2012-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9a6e91ee52f09d1ff0487978b7e21a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6beccffb5be5001a02677e1b3f453737
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b21044576ab46780e56c0f599d9fb2bd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fbcf433fd3a4bd5eb9561b6a2fba827 |
| publicationDate |
2015-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-104395284-A |
| titleOfInvention |
Method for preparing quinoline derivatives |
| abstract |
The invention discloses a method for preparing a compound of formula I, the method comprising the following steps: wherein R 1 is halo; R 2 is halo; R 3 is (C 1 -C 6 ) alkyl or optionally (C 1 -C 6 )alkyl substituted by heterocycloalkyl; R 4 is (C 1 -C 6 )alkyl; and Q is CH or N; including: (a) 1,1-cyclopropane dicarboxylate contacting the acid with thionyl chloride in a polar aprotic solvent; (b) adding and tertiary amine base to the mixture of step (a) to form a compound of formula A; and (c) combining the compound of formula A with the amine of formula B Coupling to form compounds of formula I. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112142619-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109836382-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109836382-A |
| priorityDate |
2011-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |