http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104387537-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F251-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F285-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F8-02 |
| filingDate | 2014-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104387537-B |
| titleOfInvention | Preparation method of thermo-sensitive chitosan polymer connected with sugar molecules |
| abstract | The invention belongs to the field of biological materials and nano-materials and particularly relates to a preparation method of a thermo-sensitive chitosan polymer connected with sugar molecules. The method comprises the specific steps of initiating atom transfer radical polymerization (ATRP) of 2-(2-methoxyethoxy) ethylmethacrylate (MEO2MA) and oligo(ethylene glycol) methacrylate (OEGMA) by taking a chitosan bromide (CS-Br) as a macroinitiator to obtain CS-g-P(MEO2MA-co-OEGMA)-Br; initiating the ATRP of hydroxyethyl methacrylate (HEMA) by taking the CS-g-P(MEO2MA-co-OEGMA)-Br as the macroinitiator to obtain CS-g-P(MEO2MA-co-OEGMA)-poly(2-hydroxyethyl methacrylate (PHEMA); performing esterification reaction and click chemistry to obtain a thermo-sensitive copolymer of which chitosan serves as a main chain and galactose is grafted. The polymer has biocompatibility, biodegradability, thermo-sensibility and liver targeting, and the polymer in a water solution can be self-assembled to form micelle, and has a wide application prospect in the fields of medicine controlled release, targeted therapy, biosensors and the like. The preparation method is simple and easy to operate, and has a great popularization and application value. Raw materials can be industrially produced. |
| priorityDate | 2014-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.