http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104387433-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4db77e423e7426a728937e54702d3eaf |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J7-0085 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 2014-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8755a55e36c43d4183b96bf649a72700 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f56f4874a4e59bc2c9230f4739888853 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70acbf52560fe9d6b20b4a7e4b447033 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99d5b6a630c2b7c69a6e4a5e41c5be69 |
| publicationDate | 2015-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104387433-A |
| titleOfInvention | A kind of preparation method of clobetasol and the preparation method of clobetasol propionate |
| abstract | The invention discloses a preparation method of clobetasol and a preparation method of clobetasol propionate, using compound I, namely 1,4,9(11)-triene androst-3,17-dione The starting material is subjected to methylation reaction, cyano substitution reaction, siloxy group protection reaction, intramolecular nucleophilic substitution reaction, brominated epoxy reaction and fluorine reaction to obtain compound VII, namely clobetasol. Compound VII was subjected to propyl esterification to obtain compound VIII, namely clobetasol propionate. The present invention uses relatively basic starting materials, the price is cheap, each step reaction is relatively easy to realize, and the yield is high; the operation of multi-step protection and deprotection is simplified, and the 21 Chlorine position directly subtracts the multi-step reaction of the upper 21-position chlorine in the current process, greatly shortens the synthetic route, improves the total yield and quality, and greatly reduces production costs. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106946963-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106946963-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114409524-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108289855-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107746420-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112028957-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107793462-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107892708-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108047296-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109206467-A |
| priorityDate | 2014-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.