| abstract |
The invention relates to a fluorescent graft degradable block polyurethane, a bone repair material and a preparation method thereof. The polyurethane is formed by grafting a pharmaceutically acceptable fluorescent component into a structure formed by polymerizing a hard segment of aliphatic diisocyanate and a soft segment of a degradable polymer chain segment of a hydroxyl-terminated polymer or block copolymer. The bone repair material is composed of the polyurethane and nano hydroxyapatite powder. The polyurethane and corresponding bone repair material have favorable biocompatibility and degradability, have the fluorescent characteristic, can be used for performing tracing evaluation on the degradation process of the block polyurethane, analyzing the mechanism of degradation and inspecting the influence of the degradation rate on the mechanical properties of the material and the tissue regeneration and reconstruction process, and provide a new visual angle and means for evaluating the biosafety of the high-polymer degradable material. The preparation technique is simple, is easy to control and operate, and has favorable application prospects in the field of biomedicine. |