http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104356140-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-22 |
| filingDate | 2014-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104356140-B |
| titleOfInvention | A kind of membrance separation preparation method of high-purity moxidectin |
| abstract | The invention discloses the membrance separation preparation method of a kind of high-purity moxidectin, belong to field of pharmaceutical chemistry technology. The method by the nimoctin solution that purifies in advance through membrane filtration; After then passing through dichloromethane extraction, Conventional concentration is adopted to remove solvent; Concentrate passes sequentially through upper protection reaction, oxidation reaction, oximation reaction, protective reaction obtain moxidectin crude product solution; Adopt membrane separation technique to filter and remove impurity; Membrance concentration technology is adopted to obtain high-purity moxidectin concentrated solution. The method of the present invention is owing to employing membrane separation technique, replace column chromatography and macroporous resin adsorption separation method, this technology not only stablizes industrialization controlled, simple, easy, save solvent load, and material solution high-temperature solvent subtractive process, thus reducing the degraded risk of product, while improving product purity, quality and yield, save the energy, reduce production cost. |
| priorityDate | 2014-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.