http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104356012-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C219-06 |
| filingDate | 2014-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104356012-B |
| titleOfInvention | The preparation method of sarpogrelate hydrochloride light degradation impurity |
| abstract | The invention belongs to pharmaceutical synthesis field, the preparation method being specifically related to a kind of sarpogrelate hydrochloride light degradation impurity. The method prepares degradation impurity II for raw material through three steps such as substitution reaction, additive reaction, one-tenth ester reactions with salicylide, and crude product purity after column chromatography for separation reaches more than 99%; Preparing sarpogrelate hydrochloride impurity III for raw material through five step reactions such as substitution reaction, additive reaction, the reaction of one-tenth ester, epoxidation reaction, reduction reactions with 2-[2-(3-methoxyphenyl) second is rare] phenol, crude product purity after column chromatography for separation reaches more than 99%; With [[2-[2-(3-methoxyphenyl) ethyl] phenoxy group] methyl] oxirane for raw material through additive reaction, amido protection, becoming the four-step reactions such as ester reaction, deprotection to prepare sarpogrelate hydrochloride degradation impurity IV, crude product purity after column chromatography for separation reaches more than 99%. The preparation method of the present invention is simple to operate, reaction temperature and; Product purity is higher, it is adaptable to impurity analysis of spectrum; Total recovery is higher. |
| priorityDate | 2014-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.