http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104353081-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-62 |
| filingDate | 2014-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104353081-B |
| titleOfInvention | High mobility group box-1 RNAi complex of targeting microglia and its preparation method and application |
| abstract | The invention discloses High mobility group box-1 RNAi complex of targeting microglia and its preparation method and application，The High mobility group box-1 RNAi complex of targeting microglia is combined into by electrostatic interaction with High mobility group box-1 RNAi by H9 V9 fusogenic peptide，H9 V9 fusogenic peptide is formed by connecting with the aminoterminal of V9 peptide by the c-terminuses of H9 peptide，This complex can utilize the guide effect of V9 peptide，Special target microglia surface specific MCP 1 receptor，While V9 peptide is with MCP 1 receptor acting，HMGB1 RNAi high-efficiency transfection enters microglia，The activation of suppression microglia，And then suppress the inflammatory reaction being mediated by microglia，Can be used for the medicine that microglia inflammation damnification after cerebral hemorrhage is treated in preparation，There is good development prospect in the therapy field of cerebral hemorrhage. |
| priorityDate | 2014-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.