| abstract |
The invention provides a chlorogenic acid crystal form-containing preparation. The crystal form is an orthorhombic crystal system, the space group is P212121, and the cell parameter are as follows: a is 7.7291(2) angstroms, b is 10.9808(2) angstroms, c is 36.5334(7) angstroms, alpha, beta and gamma are respectively 90.00 degrees, Z is 8, and the cell volume is 3100.65(11) cubic angstroms. The content of the chlorogenic acid crystal form in the preparation is 10-500mg/g. The preparation is advantageous to exertion of drug bioavailability and other curative effects, is an advantageous crystal form for playing curative effect of chlorogenic acid, and plays excellent clinical curative effects on medicines for treating tumor, psoriasis and other immune system diseases, resisting oxidation, protecting liver and gallbladder, treating cardiovascular diseases, resisting viruses and the like. The invention further provides an effective dosage of the chlorogenic acid crystal form-containing preparation in clinical application, and provides a safe and effective basis of the chlorogenic acid crystal form-containing preparation for clinical application. |