| abstract |
In an aspect, the present invention relates to the compound with following formula： Wherein R 1 、R 2 、R 3 、R 7 、R 8 , Z, X, b and c be to be defined as in the description, or its pharmaceutically acceptable salt.These compounds are nitric oxide donors and with enkephalinase inhibitory activity.In another aspect, the present invention relates to the medical composition comprising the compound；Use the method for the compound；And prepare the method and intermediate of the compound. |