http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104341474-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J4-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J19-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J4-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H17-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 |
| filingDate | 2014-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104341474-B |
| titleOfInvention | The preparation method and its salt-forming reaction device of a kind of erythromycin lactobionate solution |
| abstract | The invention belongs to field of pharmaceutical chemistry technology, the preparation method and salt-forming reaction device of a kind of erythromycin lactobionate solution are disclosed.The preparation method for the erythromycin lactobionate solution that the present invention is provided includes：Sodium lactonic is taken, exchanges, separate through cation exchange resin column, lactose acid solution is prepared；Erythromycin, water for injection are taken, it is blended, obtain erythromycin suspension；Gained lactose acid solution is taken, is added drop-wise in gained erythromycin suspension, is occurred salt-forming reaction, through constant volume, decarburization, produce；Wherein, the concentration of erythromycin suspension is 60mg/mL~120mg/mL；The concentration of lactose acid solution is 145g/L~225g/L；The rate of addition of lactose acid solution is 320mL/min~380mL/min.The preparation method that the present invention is provided significantly improves the yield of erythromycin lactobionate, reduces relevant content of material, the quality of erythromycin lactobionate solution is more stablized. |
| priorityDate | 2014-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.