| abstract |
Class I tanshinone IIA derivatives, conjugate is formed by linking arm and phosphocreatine and the like, shown in structure such as formula (I).Wherein n=1 3, m=0 3, R1 and R2 independently represent hydrogen atom, C1 5 alkyl, cycloalkyl, alkenyl, alkynyl, and R1 and R2 can also form 36 yuan of rings, and M is metal ion, such as sodium.Such compound improves the water solubility of whole molecule by the sodium ascorbyl phosphate in phosphocreatine on the basis of the activity of tanshinone IIA is maintained；And the phosphocreatine fragment in molecule can play the double protection to cardiac muscle. |