| abstract |
The invention discloses a deuterated acetylene derivative, its pharmaceutical composition and application. The pharmaceutical composition comprises a therapeutically effective amount of deuterated acetylene derivative (I), its pharmaceutically acceptable salt, stereoisomer, solvate, polymorph, tautomer, metabolite and its One or more of the prodrugs, and at least one pharmaceutically acceptable auxiliary material. The present invention also provides the deuterated acetylene derivative (I), its pharmaceutically acceptable salt, stereoisomer, solvate, polymorph, tautomer, metabolite or its prodrug, Or the application of the pharmaceutical composition in the preparation of one or more protein kinase inhibitors, and the application in the preparation of drugs for treating and/or preventing tumors. The deuterated acetylene derivative (I) of the present invention can effectively inhibit the activity of more than one protein kinase and the growth of tumor cells, and exhibit excellent pharmacokinetic properties and in vitro and in vivo drug effects. (I) |