http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104341390-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 2014-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104341390-B |
| titleOfInvention | A kind of botanical pesticide nicotine and the method for asymmetric synthesis of anabasine |
| abstract | The present invention relates to a kind of botanical pesticide nicotine and the method for asymmetric synthesis of anabasine.With cheap and easy to get 2,5 dibromo pyridines are that initiation material obtains hydrogenatable precursor cyclic imide through two steps, and obtain important hydrogenated products intermediate with high enantioselectivity under the induction of chiral catalyst iridium phosphine quinoline, intermediate i.e. can get left-handed nicotine through two steps, and intermediate just can be converted into left-handed anabasine through a step.The asymmetric hydrogenation of the cyclic imide containing pyridine groups is the committed step of the method.The present invention uses iridium phosphine oxazoline chiral catalyst be catalyzed this asymmetric hydrogenation and can be worth to key intermediate with the highest ee, then pass through methylate and reduction go bromine two-step reaction convert obtain target product natural nicotine (nicotine) and anabasine (anabasine).Stable operation of the present invention, purity is high, low cost. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2780283-C1 |
| priorityDate | 2014-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.