http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104338150-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_312804bd9173794765ee392ae754b1f4 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2014-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35d8ae84002310dce2c41662a5cb4b38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c006047a9cd6d4a827c8eb4854baacd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb25d49bb0ce41abd41ec9baaf728af8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f52c1087963368db56331e021494869 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3b0b008ff0f3b5d1dfcd8b6fc96059c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b88b634b31352d076994cf9066e3267 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_707fb6efd652df00cf883bc3ca866381 |
| publicationDate | 2015-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104338150-A |
| titleOfInvention | Application of PCBP1 gene in preparing radiotherapy sensitivity enhancing kit |
| abstract | The invention discloses application of a PCBP1 gene in preparing a radiotherapy sensitivity enhancing kit, and in particular relates to application of the PCBP1 gene in preparing a sensitivity enhancing kit for tumor radiotherapy utilizing ionizing radiation including heavy ion rays. The nucleotide sequence of the PCBP1 gene is as shown in SEQ ID NO.1 and the PCBP1 gene is established in eukaryotic expression plasmid. Together with heavy ion beams, the PCBP1 gene regulates and controls expression of the CD44v6 gene related to tumor metastasis and invasion, inhibits proliferation, migration and invasion of HeLa tumor cells, remarkably down-regulates the cell cycle regulatory protein Cyclin D1, prompts cells to generate G0/G1 retardation, enhances the radiotherapy sensitivity of HeLa cells, up-regulates pro-apoptotic protein Tap73 and expression of the mitochondria apoptosis pathway MCL, down-regulates the apoptosis inhibition DelNp73 protein, and induces apoptosis of many HeLa cells. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106591361-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111757933-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019153008-A1 |
| priorityDate | 2014-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.