http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104338134-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-50 |
| filingDate | 2013-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104338134-B |
| titleOfInvention | A kind of autophagy inhibitor and arginase medicinal composition and application thereof |
| abstract | The present invention relates to field of biological pharmacy, there is provided a kind of medicinal composition of new treatment tumour, and in particular to a kind of autophagy inhibitor and arginase medicinal composition and application thereof；The medicinal composition is used to treat tumour.The medicinal composition can significantly increase the antitumor activity of arginase in vitro；The immunogenicity of people's recombinant arginase can be reduced, extends the half-life period of arginase in vivo.The present invention provides the arginase of polysialic acids modification, the arginase of polysialic acids modification is reacted into conjugate by the polysialic acids activated in the presence of sodium cyanoborohydride with arginase；The medicinal composition of the present invention can strengthen lethal effect of the arginase to tumour, the effect of strengthening arginase, the effect of especially treating melanoma and breast cancer. |
| priorityDate | 2013-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 250.