abstract |
The present invention relates to use of compounds for the delivery of nucleid acids as well as the compounds and the nucleid acides, especially conjugates of siRNA. The application also discloses a stable siRNA, the stable siRNA is connected with the compound in a covalent manner and is applied in combination with a delivery polymer to realizing reduction of mRNA in a human body. Specifically, the invention provides a use of the compound of a formular (1) in nucleid delivery. |