| abstract |
The present invention relates to a substituted dihydroindane amide compound represented by general formula I and a pharmaceutically acceptable salt thereof, a preparation method and application thereof. The present invention also provides their pharmaceutical composition, in vitro and in vivo anti-tumor effect research results and acute toxicity research results, the anti-tumor drug obtained in the present invention replaces dihydroindane amide compounds, and has better anti-tumor activity and safety Sex, especially anti-imatinib-resistant tumors, can be used in the treatment of leukemia, gastrointestinal stromal tumors, lung cancer, colon cancer, ovarian cancer and kidney cancer and other tumors, so the therapeutic window is wide, so in medicine It is very valuable as an anti-tumor agent in the field. |