| abstract |
The invention discloses a method for efficiently catalytically synthesizing quinoline derivatives, which belongs to the technical field of organic synthesis. In this synthesis reaction, the mol ratio of active α-methyl or methylene carbonyl compound and 2-aminoacetophenone is 1: 1, and the molar weight of polysulfonate acidic ionic liquid catalyst is 7% of used 2-aminoacetophenone ～10%, the volume of reaction solvent 75% ethanol aqueous solution (ml) is 3～5 times of 2-aminoacetophenone molar weight (mmol), the reflux reaction time is 5～25min, cool to room temperature after reaction finishes, filter , and the resulting filter residue was vacuum-dried to obtain pure quinoline derivatives. Compared with other synthetic methods using acidic ionic liquids as catalysts, the present invention has the advantages of high catalyst catalytic activity, less usage and less loss during recycling, simple, convenient and economical whole synthesis process, and is convenient for large-scale industrial production. |