http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104293875-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-00 |
| filingDate | 2014-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104293875-B |
| titleOfInvention | The method that biological enzyme prepares (S) 2 chlorobenzene glycine methyl ester single enantiomer |
| abstract | The invention discloses the method that one kind prepares (S) 2 chlorobenzene glycine methyl ester single enantiomer using biological enzyme, comprise the following steps：The chlorobenzene glycine methyl ester of racemic 2 and buffer solution of sodium phosphate are added in the reactor of 30 DEG C of constant temperature water bath; penicillin G acylase is added after stirring; it is 100 500r/min to control speed of agitator; the 20 60 hours reaction time of control; it is stirred continuously until that reaction terminates, finally reclaims penicillin G acylase.The present invention is advantageous in that：Catalyst is made using PGA; using its activity, high selectivity and the selectivity to substrate; reacted under normal temperature, normal pressure; one step prepares (S) 2 chlorobenzene glycine methyl ester; both protection and the deprotection process of reactive group in chlorobenzene glycine had been eliminated; optical purity (S) 2 chlorobenzene glycine methyl ester single enantiomer higher is obtained again, and enantiomer is to value up to more than 95%；Method of the present invention operating process is simple and direct easy to control, and preparation process energy consumption is low, and discharge is few, is environment-friendly Pallution-free preparation method. |
| priorityDate | 2014-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.