http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104293740-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-295 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-215 |
| filingDate | 2013-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104293740-B |
| titleOfInvention | Recombinant baculovirus of surface display SARS bivalent antigens and its preparation method and application |
| abstract | The invention discloses a kind of recombinant baculovirus of surface display SARS bivalent antigens and its preparation method and application, the virus is to be inserted into donor plasmid by recombinant protein SP N TM and SP RBD TM encoding gene and carry out homologous recombination by swivel base and shuttle vector Bacmid genome, obtain recombinant baculovirus genomic DNA, then the genomic DNA is transfected into bombyx mori cell, the recombinant baculovirus being packaged to be in the cell；The membrane-spanning domain TM that wherein recombinant protein SP N TM are signal peptide SP, the C ends connection GP64 for connecting GP64 by the N ends of the N protein of SARS virus is formed；SP RBD TM are to connect SP by the N ends of the RBD albumen of SARS virus, and C ends connection TM is formed.The N protein of SARS virus and RBD GFPs are shown there is good immunogenicity by the recombinant baculovirus in viral capsid surface. |
| priorityDate | 2013-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 554.